Definition Of Cell Homing

This process was initially described for hematopoietic stem cells HSCs which migrate after transplantation from peripheral blood PB to stem cell niches located in the bone marrow BM microenvironment. Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialized blood vessels called high endothelial venules.

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Several different classes of lymphocyte homing receptors have been identified and they appear to target different surface molecules addressins on high endothelial venules in different tissues.

Definition of cell homing. Hōmĭng Movement of a cell toward specific tissues cytokines or antigens. Homing mechanical moving a mechanical system to a reference position. 1 Relating to an animals ability to return to its territory after travelling away from it.

Chemokines are a family of small cytokines or signaling proteins secreted by cells. They are chemotactic cytokines. US Department of Defense 2005.

Abstract Rather like a satellite navigation system directing a vehicle to a particular destination defined by post-code immune cells have homing molecules or immune post-codes enabling them to be recruited to specific organs such as the intestine or skin. Redirected from B-cell-homing chemokine CXCL13 A gene on chromosome 4q21 that encodes a CXC-type chemokine strongly expressed in the follicles of the spleen lymph nodes and Peyers patches which acts as a homing signal for B cells by stimulating calcium influx into and chemotaxis of cells expressing Burkitts lymphoma receptor 1 BLR-1. Homing horse a racehorse.

Homing The technique whereby a mobile station directs itself or is directed towards a source of primary or reflected energy or to a specified point. Such a nonmechanistic definition is appropriate given the current absence of a definitive MSC homing mechanism unlike the well-characterized leukocyte adhesion cascade that defines leukocyte homing. Cytokine proteins are classified as chemokines according to behavior and structural characteristics.

The homing endonucleases are a collection of endonucleases encoded either as freestanding genes within introns as fusions with host proteins or as self-splicing inteins. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. Homing hematopoietic a process of cellular migration.

Dictionary of Military and Associated Terms. T cell homing and exercise Lymphocytes recirculate between the blood and lymph moving by routes that take them through various lymphoid and non-lymphoid organs in order to search for their cognate antigen. This homing phenomenon may be related to tumour cell recognition of specific exit sites from the circulation or to awareness of a particularly favourableor forbiddingsoil of another tissue.

Naïve and effectormemory T cells provide distinct repertoires of receptors and ligands that constitute their ability to. MSC homing is defined as the arrest of MSCs within the vasculature of a tissue followed by transmigration across the endothelium. B cell and T cell lymphocytes interact with a variety of cells as part of their immune function circulating and homing in on specific stimuli in tissues like inflammatory signals.

Adhesion Molecules on Lymphocyte Pathway NCI ThesaurusBIOCARTA. Lymphocyte homing to the secondary lymphoid organs is a well-known process initiated by the rolling of lymphocytes on high endothelial venules HEV of lymph nodes Rosen 2004. A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cellcell interactions cell adhesion and cell migration and which is a receptor for hyaluronic acid.

Multiple homing two types of telephone connections of a terminal facility. Stem cell homing is a process whereby stem cells respond to gradients of chemoattractants by migrating up these gradients and lodging within specific tissue areas 13. Their homing abilities could also provide scientists with new clues to the long-debated role of the Earths magnetic fields in animal movements and migrations.

This may occur because of an affinity that exists between receptor proteins on. They catalyze the hydrolysis of genomic DNA within the cells that synthesize them but do so at very few or even singular locations. In addition to being known for mediating chemotaxis chemokines are all.

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